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2qsf

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{{STRUCTURE_2qsf| PDB=2qsf | SCENE= }}
 
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===Crystal structure of the Rad4-Rad23 complex===
 
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{{ABSTRACT_PUBMED_17882165}}
 
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==Function==
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==Crystal structure of the Rad4-Rad23 complex==
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[[http://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST]] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. [[http://www.uniprot.org/uniprot/RAD23_YEAST RAD23_YEAST]] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
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<StructureSection load='2qsf' size='340' side='right'caption='[[2qsf]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QSF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsf OCA], [https://pdbe.org/2qsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qsf RCSB], [https://www.ebi.ac.uk/pdbsum/2qsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qsf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qs/2qsf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qsf ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[2qsf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSF OCA].
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*[[DNA repair protein Rad4|DNA repair protein Rad4]]
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*[[UV excision repair protein|UV excision repair protein]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017882165</ref><references group="xtra"/><references/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Min, J H.]]
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[[Category: Min J-H]]
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[[Category: Pavletich, N P.]]
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[[Category: Pavletich NP]]
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[[Category: Alpha-beta structure]]
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[[Category: Beta hairpin]]
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[[Category: Dna binding protein]]
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[[Category: Dna repair]]
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[[Category: Dna-damage recognition]]
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[[Category: Nucleotide excision repair]]
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[[Category: Transglutaminase fold]]
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[[Category: Xeroderma pigmentosum]]
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Current revision

Crystal structure of the Rad4-Rad23 complex

PDB ID 2qsf

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