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2r24

From Proteopedia

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{{Seed}}
 
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[[Image:2r24.jpg|left|200px]]
 
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<!--
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==Human Aldose Reductase structure==
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The line below this paragraph, containing "STRUCTURE_2r24", creates the "Structure Box" on the page.
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<StructureSection load='2r24' size='340' side='right'caption='[[2r24]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R24 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution|Resolution]] 1.752&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_2r24| PDB=2r24 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r24 OCA], [https://pdbe.org/2r24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r24 RCSB], [https://www.ebi.ac.uk/pdbsum/2r24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r24 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r24_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r24 ConSurf].
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<div style="clear:both"></div>
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===Human Aldose Reductase structure===
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18250329}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18250329 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18250329}}
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==About this Structure==
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2R24 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R24 OCA].
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==Reference==
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Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase., Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. Epub 2008 Feb 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18250329 18250329]
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Afonine, P.]]
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[[Category: Large Structures]]
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[[Category: Blakeley, M.]]
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[[Category: Afonine P]]
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[[Category: Cachau, R.]]
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[[Category: Blakeley MP]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Cachau R]]
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[[Category: Ginell, S.]]
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[[Category: Cousido-Siah A]]
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[[Category: Haertlein, M.]]
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[[Category: Ginell S]]
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[[Category: Hazemann, I.]]
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[[Category: Haertlein M]]
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[[Category: Joachimiak, A.]]
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[[Category: Hazemann I]]
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[[Category: Meilleur, F.]]
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[[Category: Joachimiak A]]
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[[Category: Mitschler, A.]]
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[[Category: Meilleur F]]
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[[Category: Myles, D.]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A.]]
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[[Category: Myles D]]
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[[Category: Ruiz, F.]]
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[[Category: Podjarny A]]
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[[Category: Ventura, O N.]]
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[[Category: Ruiz F]]
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[[Category: Acetylation]]
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[[Category: Ventura ON]]
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[[Category: Beta/alpha-8 tim barrel]]
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[[Category: Cataract]]
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[[Category: Cytoplasm]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:24:48 2008''
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Current revision

Human Aldose Reductase structure

PDB ID 2r24

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