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2r4g

From Proteopedia

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[[Image:2r4g.png|left|200px]]
 
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{{STRUCTURE_2r4g| PDB=2r4g | SCENE= }}
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==The high resolution structure of the RNA-binding domain of telomerase==
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<StructureSection load='2r4g' size='340' side='right'caption='[[2r4g]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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===The high resolution structure of the RNA-binding domain of telomerase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r4g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4G FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17997966}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4g OCA], [https://pdbe.org/2r4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4g RCSB], [https://www.ebi.ac.uk/pdbsum/2r4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4g ProSAT]</span></td></tr>
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[[2r4g]] is a 1 chain structure of [[Reverse transcriptase]], [[Telomerase]] and [[Telomerase Reverse Transcriptase]] with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4G OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4g ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Reverse transcriptase|Reverse transcriptase]]
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*[[Telomerase 3D structures|Telomerase 3D structures]]
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*[[Telomerase|Telomerase]]
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== References ==
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*[[Telomerase Reverse Transcriptase|Telomerase Reverse Transcriptase]]
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017997966</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: RNA-directed DNA polymerase]]
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[[Category: Tetrahymena thermophila]]
[[Category: Tetrahymena thermophila]]
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[[Category: Rouda, S.]]
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[[Category: Rouda S]]
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[[Category: Skordalakes, E.]]
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[[Category: Skordalakes E]]
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[[Category: Chromosomal protein]]
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[[Category: Dna-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Rna-directed dna polymerase]]
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[[Category: Telomerase]]
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[[Category: Telomere]]
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[[Category: Transferase]]
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Current revision

The high resolution structure of the RNA-binding domain of telomerase

PDB ID 2r4g

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