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2r6p

From Proteopedia

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{{Seed}}
 
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[[Image:2r6p.png|left|200px]]
 
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==Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.==
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The line below this paragraph, containing "STRUCTURE_2r6p", creates the "Structure Box" on the page.
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<SX load='2r6p' size='340' side='right' viewer='molstar' caption='[[2r6p]], [[Resolution|resolution]] 24.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r6p]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2_Puerto_Rico/PR159-S1/1969 Dengue virus 2 Puerto Rico/PR159-S1/1969] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R6P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 24&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6p OCA], [https://pdbe.org/2r6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r6p RCSB], [https://www.ebi.ac.uk/pdbsum/2r6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r6p ProSAT]</span></td></tr>
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{{STRUCTURE_2r6p| PDB=2r6p | SCENE= }}
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</table>
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== Function ==
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===Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.===
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[https://www.uniprot.org/uniprot/Q66394_9FLAV Q66394_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_18264114}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18264114 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/2r6p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18264114}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r6p ConSurf].
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2R6P is a 7 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Viruses Viruses]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6P OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</SX>
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<ref group="xtra">PMID:18264114</ref><references group="xtra"/>
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[[Category: Dengue Virus]]
[[Category: Dengue Virus]]
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[[Category: Dengue virus 2 Puerto Rico/PR159-S1/1969]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Viruses]]
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[[Category: Chipman PR]]
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[[Category: Chipman, P R.]]
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[[Category: Holdaway HA]]
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[[Category: Holdaway, H A.]]
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[[Category: Kostyuchenko VK]]
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[[Category: Kostyuchenko, V K.]]
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[[Category: Kuhn RJ]]
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[[Category: Kuhn, R J]]
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[[Category: Lok SM]]
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[[Category: Lok, S M.]]
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[[Category: Rossmann MG]]
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[[Category: Rossmann, M G]]
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[[Category: Dengue]]
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[[Category: Fab]]
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[[Category: Icosahedral virus]]
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[[Category: Neutralization]]
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[[Category: Virus]]
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[[Category: Virus/immune system complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 21 09:44:03 2010''
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Current revision

Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.

2r6p, resolution 24.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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