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2r6p
From Proteopedia
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| - | [[Image:2r6p.png|left|200px]] | ||
| - | + | ==Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.== | |
| - | + | <SX load='2r6p' size='340' side='right' viewer='molstar' caption='[[2r6p]], [[Resolution|resolution]] 24.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2r6p]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2_Puerto_Rico/PR159-S1/1969 Dengue virus 2 Puerto Rico/PR159-S1/1969] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R6P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 24Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6p OCA], [https://pdbe.org/2r6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r6p RCSB], [https://www.ebi.ac.uk/pdbsum/2r6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r6p ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2r6p]] is a 7 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/Q66394_9FLAV Q66394_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774] | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/2r6p_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r6p ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </SX> | ||
[[Category: Dengue Virus]] | [[Category: Dengue Virus]] | ||
| - | [[Category: Dengue virus 2 | + | [[Category: Dengue virus 2 Puerto Rico/PR159-S1/1969]] |
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Chipman | + | [[Category: Chipman PR]] |
| - | [[Category: Holdaway | + | [[Category: Holdaway HA]] |
| - | [[Category: Kostyuchenko | + | [[Category: Kostyuchenko VK]] |
| - | [[Category: Kuhn | + | [[Category: Kuhn RJ]] |
| - | [[Category: Lok | + | [[Category: Lok SM]] |
| - | [[Category: Rossmann | + | [[Category: Rossmann MG]] |
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Current revision
Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.
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