2r8h

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[[Image:2r8h.png|left|200px]]
 
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==Selectivity of Nucleoside Triphosphate Incorporation Opposite 1,N2-Propanodeoxyguanosine (PdG) by the Sulfolobus solfataricus DNA Polymerase Dpo4 Polymerase==
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The line below this paragraph, containing "STRUCTURE_2r8h", creates the "Structure Box" on the page.
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<StructureSection load='2r8h' size='340' side='right'caption='[[2r8h]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r8h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R8H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=P:2-DEOXY-N1,N2-PROPANO+GUANOSINE+MONOPHOSPHATE'>P</scene></td></tr>
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{{STRUCTURE_2r8h| PDB=2r8h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r8h OCA], [https://pdbe.org/2r8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r8h RCSB], [https://www.ebi.ac.uk/pdbsum/2r8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r8h ProSAT]</span></td></tr>
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</table>
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===Selectivity of Nucleoside Triphosphate Incorporation Opposite 1,N2-Propanodeoxyguanosine (PdG) by the Sulfolobus solfataricus DNA Polymerase Dpo4 Polymerase===
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== Function ==
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[https://www.uniprot.org/uniprot/DPO4_SACS2 DPO4_SACS2] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18563918}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18563918 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/2r8h_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18563918}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2r8h]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8H OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r8h ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018563918</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Egli M]]
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[[Category: Egli, M.]]
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[[Category: Marnette LJ]]
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[[Category: Marnette, L J.]]
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[[Category: Saleh S]]
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[[Category: Saleh, S.]]
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[[Category: Stone MP]]
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[[Category: Stone, M P.]]
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[[Category: Wang Y]]
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[[Category: Wang, Y.]]
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[[Category: Exocyclic adduct]]
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[[Category: Frameshifting]]
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[[Category: Polymerase]]
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[[Category: Replication]]
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[[Category: Replication bypass]]
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[[Category: Transferase-dna complex]]
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[[Category: Translesion]]
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Current revision

Selectivity of Nucleoside Triphosphate Incorporation Opposite 1,N2-Propanodeoxyguanosine (PdG) by the Sulfolobus solfataricus DNA Polymerase Dpo4 Polymerase

PDB ID 2r8h

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