2tmv

<table><tr><td colspan='2'>[[2tmv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tmv Tmv]. The January 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Tobacco Mosaic Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_1 10.2210/rcsb_pdb/mom_2009_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2TMV FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2tmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tmv OCA], [http://pdbe.org/2tmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2tmv RCSB], [http://www.ebi.ac.uk/pdbsum/2tmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2tmv ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CAPSD_TMV CAPSD_TMV]] Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.

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== Publication Abstract from PubMed ==

The structure of tobacco mosaic virus (TMV) has been determined by fiber diffraction methods at 2.9 A resolution, and refined by restrained least-squares to an R-factor of 0.096. Protein-nucleic acid interactions are clearly visible. The final model contains all of the non-hydrogen atoms of the RNA and the protein, 71 water molecules, and two calcium-binding sites. Viral disassembly is driven by electrostatic repulsions between the charges in two carboxyl-carboxylate pairs and a phosphate-carboxylate pair. The phosphate-carboxylate pair and at least one of the carboxyl-carboxylate pairs appear to be calcium-binding sites. Nucleotide specificity, enabling TMV to recognize its own RNA by a repeating pattern of guanine residues, is provided by two guanine-specific hydrogen bonds in one of the three base-binding sites.

Visualization of protein-nucleic acid interactions in a virus. Refined structure of intact tobacco mosaic virus at 2.9 A resolution by X-ray fiber diffraction.,Namba K, Pattanayek R, Stubbs G J Mol Biol. 1989 Jul 20;208(2):307-25. PMID:2769760<ref>PMID:2769760</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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*[[Teaching Scenes%2C Tutorials%2C and Educators' Pages|Teaching Scenes%2C Tutorials%2C and Educators' Pages]]

*[[Virus coat protein|Virus coat protein]]

[[Category: Tmv]]

[[Category: Namba, K]]

[[Category: Pattanayek, R]]

[[Category: Stubbs, G]]

[[Category: Virus-rna complex]]