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391d

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[[Image:391d.gif|left|200px]]
 
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==STRUCTURAL VARIABILITY AND NEW INTERMOLECULAR INTERACTIONS OF Z-DNA IN CRYSTALS OF D(PCPGPCPGPCPG)==
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The line below this paragraph, containing "STRUCTURE_391d", creates the "Structure Box" on the page.
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<StructureSection load='391d' size='340' side='right'caption='[[391d]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[391d]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=391D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=391D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=391d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=391d OCA], [https://pdbe.org/391d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=391d RCSB], [https://www.ebi.ac.uk/pdbsum/391d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=391d ProSAT]</span></td></tr>
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{{STRUCTURE_391d| PDB=391d | SCENE= }}
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</table>
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'''STRUCTURAL VARIABILITY AND NEW INTERMOLECULAR INTERACTIONS OF Z-DNA IN CRYSTALS OF D(PCPGPCPGPCPG)'''
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==See Also==
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*[[Z-DNA|Z-DNA]]
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__TOC__
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==Overview==
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</StructureSection>
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We have determined the single crystal x-ray structure of the synthetic DNA hexamer d(pCpGpCpGpCpG) in two different crystal forms. The hexamer pCGCGCG has the Z-DNA conformation and in both cases the asymmetric unit contains more than one Z-DNA duplex. Crystals belong to the space group C222(1) with a = 69.73, b = 52.63, and c = 26.21 A, and to the space group P2(1) with a = 49.87, b = 41.26, c = 21.91 A, and gamma = 97.12 degrees. Both crystals show new crystal packing modes. The molecules also show striking new features when compared with previously determined Z-DNA structures: 1) the bases in one duplex have a large inclination with respect to the helical axis, which alters the overall shape of the molecule. 2) Some cytosine nitrogens interact by hydrogen bonding with phosphates in neighbor molecules. Similar base-phosphate interactions had been previously detected in some B-DNA crystals. 3) Basepair stacking between the ends of neighbor molecules is variable and no helical continuity is maintained between contiguous hexamer duplexes.
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[[Category: Large Structures]]
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[[Category: Ivanova E]]
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==About this Structure==
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[[Category: Malinina L]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=391D OCA].
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[[Category: Nekrasov Y]]
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[[Category: Subirana JA]]
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==Reference==
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[[Category: Tereshko V]]
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Structural variability and new intermolecular interactions of Z-DNA in crystals of d(pCpGpCpGpCpG)., Malinina L, Tereshko V, Ivanova E, Subirana JA, Zarytova V, Nekrasov Y, Biophys J. 1998 May;74(5):2482-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9591674 9591674]
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[[Category: Zarytova V]]
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[[Category: Ivanova, E.]]
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[[Category: Malinina, L.]]
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[[Category: Nekrasov, Y.]]
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[[Category: Subirana, J A.]]
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[[Category: Tereshko, V.]]
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[[Category: Zarytova, V.]]
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[[Category: Double helix]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:18:32 2008''
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STRUCTURAL VARIABILITY AND NEW INTERMOLECULAR INTERACTIONS OF Z-DNA IN CRYSTALS OF D(PCPGPCPGPCPG)

PDB ID 391d

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