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3bgd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3bgd is ON HOLD until Paper Publication Authors: Peng, Y., Yee, V.C. Description: Methyltransferase ''Page seeded by [http://oca.weizmann.ac.il/o...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Thiopurine S-Methyltransferase== | |
| - | + | <StructureSection load='3bgd' size='340' side='right'caption='[[3bgd]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3bgd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PM6:9H-PURINE-6-THIOL'>PM6</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgd OCA], [https://pdbe.org/3bgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgd RCSB], [https://www.ebi.ac.uk/pdbsum/3bgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgd ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TPMT_MOUSE TPMT_MOUSE] Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgd_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgd ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Peng Y]] | ||
| + | [[Category: Yee VC]] | ||
Current revision
Thiopurine S-Methyltransferase
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