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3bh0

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[[Image:3bh0.jpg|left|200px]]
 
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==ATPase Domain of G40P==
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The line below this paragraph, containing "STRUCTURE_3bh0", creates the "Structure Box" on the page.
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<StructureSection load='3bh0' size='340' side='right'caption='[[3bh0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_SPP1 Bacillus phage SPP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BH0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bh0 OCA], [https://pdbe.org/3bh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bh0 RCSB], [https://www.ebi.ac.uk/pdbsum/3bh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bh0 ProSAT]</span></td></tr>
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{{STRUCTURE_3bh0| PDB=3bh0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q38152_BPSPP Q38152_BPSPP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/3bh0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bh0 ConSurf].
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<div style="clear:both"></div>
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'''ATPase Domain of G40P'''
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Helicases are essential enzymes for DNA replication, a fundamental process in all living organisms. The DnaB family are hexameric replicative helicases that unwind duplex DNA and coordinate with RNA primase and other proteins at the replication fork in prokaryotes. Here, we report the full-length crystal structure of G40P, a DnaB family helicase. The hexamer complex reveals an unusual architectural feature and a new type of assembly mechanism. The hexamer has two tiers: a three-fold symmetric N-terminal tier and a six-fold symmetric C-terminal tier. Monomers with two different conformations, termed cis and trans, come together to provide a topological solution for the dual symmetry within a hexamer. Structure-guided mutational studies indicate an important role for the N-terminal tier in binding primase and regulating primase-mediated stimulation of helicase activity. This study provides insights into the structural and functional interplay between G40P helicase and DnaG primase.
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[[Category: Bacillus phage SPP1]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Chen XS]]
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3BH0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_spp1 Bacillus phage spp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BH0 OCA].
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[[Category: Holden LG]]
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[[Category: Klein MG]]
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==Reference==
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[[Category: Tokonzaba E]]
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The structure of a DnaB-family replicative helicase and its interactions with primase., Wang G, Klein MG, Tokonzaba E, Zhang Y, Holden LG, Chen XS, Nat Struct Mol Biol. 2008 Jan;15(1):94-100. Epub 2007 Dec 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18157148 18157148]
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[[Category: Wang G]]
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[[Category: Bacillus phage spp1]]
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[[Category: Zhang Y]]
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[[Category: Single protein]]
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[[Category: Chen, X S.]]
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[[Category: Holden, L G.]]
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[[Category: Klein, M G.]]
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[[Category: Tokonzaba, E.]]
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[[Category: Wang, G.]]
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[[Category: Zhang, Y.]]
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[[Category: Atpase]]
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[[Category: Helicase]]
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[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:45:19 2008''
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Current revision

ATPase Domain of G40P

PDB ID 3bh0

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