3bjt

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(New page: 200px<br /><applet load="3bjt" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bjt, resolution 2.50&Aring;" /> '''Pyruvate kinase M2 i...)
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[[Image:3bjt.jpg|left|200px]]<br /><applet load="3bjt" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="3bjt, resolution 2.50&Aring;" />
 
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'''Pyruvate kinase M2 is a phosphotyrosine binding protein'''<br />
 
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==About this Structure==
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==Pyruvate kinase M2 is a phosphotyrosine binding protein==
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3BJT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=OXL:'>OXL</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] Known structural/functional Sites: <scene name='pdbsite=AC1:Oxl+Binding+Site+For+Residue+A+901'>AC1</scene>, <scene name='pdbsite=AC2:Oxl+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:Oxl+Binding+Site+For+Residue+C+903'>AC3</scene>, <scene name='pdbsite=AC4:Oxl+Binding+Site+For+Residue+D+904'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+A+1'>AC5</scene>, <scene name='pdbsite=AC6:Mg+Binding+Site+For+Residue+B+903'>AC6</scene>, <scene name='pdbsite=AC7:Mg+Binding+Site+For+Residue+C+904'>AC7</scene> and <scene name='pdbsite=AC8:Mg+Binding+Site+For+Residue+D+905'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJT OCA].
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<StructureSection load='3bjt' size='340' side='right'caption='[[3bjt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Pyruvate kinase]]
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<table><tr><td colspan='2'>[[3bjt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BJT FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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[[Category: Wu, N.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
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[[Category: MG]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjt OCA], [https://pdbe.org/3bjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bjt RCSB], [https://www.ebi.ac.uk/pdbsum/3bjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjt ProSAT]</span></td></tr>
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[[Category: OXL]]
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</table>
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[[Category: acetylation]]
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== Function ==
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[[Category: allosteric enzyme]]
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[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
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[[Category: alternative splicing]]
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== Evolutionary Conservation ==
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[[Category: glycolysis]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: magnesium]]
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Check<jmol>
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[[Category: metal-binding]]
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<jmolCheckbox>
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[[Category: phosphoprotein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjt_consurf.spt"</scriptWhenChecked>
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[[Category: polymorphism]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: pyruvate kinase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: transferase]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bjt ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 5 13:23:58 2008''
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==See Also==
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*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Wu N]]

Current revision

Pyruvate kinase M2 is a phosphotyrosine binding protein

PDB ID 3bjt

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