3bqj

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[[Image:3bqj.jpg|left|200px]]
 
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==VA387 polypeptide==
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The line below this paragraph, containing "STRUCTURE_3bqj", creates the "Structure Box" on the page.
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<StructureSection load='3bqj' size='340' side='right'caption='[[3bqj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_isolates Norovirus isolates]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BQJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bqj OCA], [https://pdbe.org/3bqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bqj RCSB], [https://www.ebi.ac.uk/pdbsum/3bqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bqj ProSAT]</span></td></tr>
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{{STRUCTURE_3bqj| PDB=3bqj | SCENE= }}
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</table>
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== Function ==
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'''VA387 polypeptide'''
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[https://www.uniprot.org/uniprot/D0VWS6_9CALI D0VWS6_9CALI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Noroviruses are positive sense, single-stranded RNA viruses that cause acute gastroenteritis. They recognize human histo-blood group antigens as receptors in a strain-specific manner. The structures presented here sought to elucidate the structural basis for differences in ligand recognition of noroviruses from different genogroups, the prototypic Norwalk virus (NV, GI-1) and VA387 (GII-4), which recognize the same A-antigen, but differ in the inability of NV to bind to the B-antigen. Two forms of the receptor-binding domain of the norovirus coat protein, the P domain and the P polypeptide, that were previously shown to differ in receptor binding and P particle formation properties were studied. Comparison of the structures of the NV P domain with and without A-trisaccharide and the NV P polypeptide reveal no major ligand-induced changes. The 2.3 A co-crystal structure reveals that the A-trisaccharide binds to the NV P domain through interactions with residues Ser377, Asp327, His329, and Ser380 in a mode distinct from that previously reported for the VA387 P domain-A trisaccharide complex. Mutational analyses confirm the importance of these residues in NV P particle binding to native A-antigen. The alpha-GalNac residue unique to the A-trisaccharide is buried deeply in the NV binding pocket, unlike in the structures of A- and B-trisaccharides bound to VA387 P domain where the alpha-fucose residue forms the most protein contacts. The A-trisaccharide binding mode seen in the NV P domain complex cannot be sterically accommodated in the VA387 P domain.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/3bqj_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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3BQJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Norovirus_isolates Norovirus isolates]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQJ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bqj ConSurf].
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Structural basis for the receptor binding specificity of the Norwalk virus., Bu W, Mamedova A, Tan M, Xia M, Jiang X, Hegde RS, J Virol. 2008 Apr 2;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18385236 18385236]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Norovirus isolates]]
[[Category: Norovirus isolates]]
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[[Category: Single protein]]
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[[Category: Bu W]]
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[[Category: Bu, W.]]
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[[Category: Hegde R]]
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[[Category: Hegde, R.]]
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[[Category: Jiang J]]
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[[Category: Jiang, J.]]
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[[Category: Mamedova A]]
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[[Category: Mamedova, A.]]
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[[Category: Tan M]]
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[[Category: Tan, M.]]
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[[Category: Two folded units p1 and p2]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:48:50 2008''
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Current revision

VA387 polypeptide

PDB ID 3bqj

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