3bxj

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{{Seed}}
 
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[[Image:3bxj.png|left|200px]]
 
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==Crystal Structure of the C2-GAP Fragment of synGAP==
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The line below this paragraph, containing "STRUCTURE_3bxj", creates the "Structure Box" on the page.
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<StructureSection load='3bxj' size='340' side='right'caption='[[3bxj]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxj OCA], [https://pdbe.org/3bxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxj RCSB], [https://www.ebi.ac.uk/pdbsum/3bxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxj ProSAT]</span></td></tr>
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{{STRUCTURE_3bxj| PDB=3bxj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYGP1_RAT SYGP1_RAT] Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.<ref>PMID:15312654</ref> <ref>PMID:15500970</ref> <ref>PMID:16537406</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/3bxj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bxj ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the C2-GAP Fragment of synGAP===
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==See Also==
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*[[Ras GTPase activating protein|Ras GTPase activating protein]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18323856}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18323856 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_18323856}}
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==About this Structure==
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3BXJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXJ OCA].
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==Reference==
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The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction., Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K, EMBO Rep. 2008 Mar 7;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18323856 18323856]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Ahmadian MR]]
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[[Category: Ahmadian, M R.]]
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[[Category: Bonneau F]]
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[[Category: Bonneau, F.]]
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[[Category: Eberth A]]
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[[Category: Eberth, A.]]
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[[Category: Gremer L]]
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[[Category: Gremer, L.]]
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[[Category: Hothorn M]]
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[[Category: Hothorn, M.]]
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[[Category: Kaschau N]]
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[[Category: Kaschau, N.]]
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[[Category: Parret A]]
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[[Category: Parret, A.]]
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[[Category: Pena V]]
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[[Category: Pena, V.]]
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[[Category: Scheffzek K]]
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[[Category: Scheffzek, K.]]
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[[Category: Alternative splicing]]
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[[Category: Gtpase activating protein]]
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[[Category: Gtpase activation]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Sh3-binding]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:46:27 2008''
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Current revision

Crystal Structure of the C2-GAP Fragment of synGAP

PDB ID 3bxj

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