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3bxl

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Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex

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@@ Line 3: / Line 3: @@
 <StructureSection load='3bxl' size='340' side='right'caption='[[3bxl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3bxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3bxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bxk|3bxk]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Calm1, Calm, Cam, Cam1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxl OCA], [https://pdbe.org/3bxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxl RCSB], [https://www.ebi.ac.uk/pdbsum/3bxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxl ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CAC1E_RAT CAC1E_RAT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
+[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Kooi, C W.Vander]]
+[[Category: Rattus norvegicus]]
-[[Category: Leahy, D J]]
+[[Category: Leahy DJ]]
-[[Category: Mori, M X]]
+[[Category: Mori MX]]
-[[Category: Yue, D T]]
+[[Category: Vander Kooi CW]]
-[[Category: Acetylation]]
+[[Category: Yue DT]]
-[[Category: Calcium channel]]
-[[Category: Calcium transport]]
-[[Category: Calcium-dependent]]
-[[Category: Calmodulin]]
-[[Category: Facillitation]]
-[[Category: Glycoprotein]]
-[[Category: Inactivation]]
-[[Category: Ion channel]]
-[[Category: Ion transport]]
-[[Category: Ionic channel]]
-[[Category: Iq domain]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Methylation]]
-[[Category: Phosphoprotein]]
-[[Category: Robetta]]
-[[Category: Signaling protein]]
-[[Category: Simulation]]
-[[Category: Transmembrane]]
-[[Category: Transport]]
-[[Category: Ubl conjugation]]
-[[Category: Voltage-gated]]
-[[Category: Voltage-gated channel]]

3bxl

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Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex

Structural highlights

Function

Evolutionary Conservation

See Also

Contents

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