3c5h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:33, 21 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3c5h.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)==
-
|PDB= 3c5h |SIZE=350|CAPTION= <scene name='initialview01'>3c5h</scene>, resolution 1.800&Aring;
+
<StructureSection load='3c5h' size='340' side='right'caption='[[3c5h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+302'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+303'>AC2</scene>, <scene name='pdbsite=AC3:Gnp+Binding+Site+For+Residue+A+301'>AC3</scene>, <scene name='pdbsite=AC4:Unx+Binding+Site+For+Residue+A+304'>AC4</scene>, <scene name='pdbsite=AC5:Unx+Binding+Site+For+Residue+A+305'>AC5</scene>, <scene name='pdbsite=AC6:Unx+Binding+Site+For+Residue+A+307'>AC6</scene> and <scene name='pdbsite=AC7:Unx+Binding+Site+For+Residue+A+308'>AC7</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
+
<table><tr><td colspan='2'>[[3c5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5H FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
|GENE= GRLF1, GRF1, KIAA1722 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5h OCA], [https://pdbe.org/3c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5h RCSB], [https://www.ebi.ac.uk/pdbsum/3c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5h ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/RHG35_HUMAN RHG35_HUMAN] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
3C5H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA].
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5h ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Bochkarev A]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards AM]]
-
[[Category: MacKenzie, F.]]
+
[[Category: MacKenzie F]]
-
[[Category: Park, H.]]
+
[[Category: Park H]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Shen L]]
-
[[Category: Shen, L.]]
+
[[Category: Tempel W]]
-
[[Category: Tempel, W.]]
+
[[Category: Tong Y]]
-
[[Category: Tong, Y.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: GNP]]
+
-
[[Category: MG]]
+
-
[[Category: UNX]]
+
-
[[Category: alternative splicing]]
+
-
[[Category: anti-oncogene]]
+
-
[[Category: cell cycle]]
+
-
[[Category: cytoplasm]]
+
-
[[Category: dna-binding]]
+
-
[[Category: glucorticoid receptor]]
+
-
[[Category: gtpase]]
+
-
[[Category: gtpase activation]]
+
-
[[Category: nucleus]]
+
-
[[Category: phosphoprotein]]
+
-
[[Category: ra]]
+
-
[[Category: repressor]]
+
-
[[Category: sgc]]
+
-
[[Category: signaling protein]]
+
-
[[Category: structural genomics consortium]]
+
-
[[Category: transcription]]
+
-
[[Category: transcription regulation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:02:41 2008''
+

Current revision

Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)

PDB ID 3c5h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c5h"
Personal tools