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3c5v

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{{Seed}}
 
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[[Image:3c5v.png|left|200px]]
 
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==PP2A-specific methylesterase apo form (PME)==
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The line below this paragraph, containing "STRUCTURE_3c5v", creates the "Structure Box" on the page.
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<StructureSection load='3c5v' size='340' side='right'caption='[[3c5v]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c5v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5v OCA], [https://pdbe.org/3c5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5v RCSB], [https://www.ebi.ac.uk/pdbsum/3c5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5v ProSAT]</span></td></tr>
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{{STRUCTURE_3c5v| PDB=3c5v | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPME1_HUMAN PPME1_HUMAN] Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.<ref>PMID:10318862</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5v ConSurf].
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<div style="clear:both"></div>
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===PP2A-specific methylesterase apo form (PME)===
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==See Also==
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*[[Methylesterase 3D structures|Methylesterase 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18394995}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18394995 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18394995}}
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==About this Structure==
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3C5V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5V OCA].
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==Reference==
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Structural mechanism of demethylation and inactivation of protein phosphatase 2A., Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y, Cell. 2008 Apr 4;133(1):154-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18394995 18394995]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chen, Y.]]
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[[Category: Chen Y]]
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[[Category: Jeffrey, P D.]]
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[[Category: Jeffrey PD]]
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[[Category: Li, Z.]]
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[[Category: Li Z]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Stock, J.]]
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[[Category: Stock J]]
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[[Category: Xing, Y.]]
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[[Category: Xing Y]]
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[[Category: Alternative splicing]]
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[[Category: Demethylase]]
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[[Category: Hydrolase]]
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[[Category: Phosphoprotein]]
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[[Category: Pp2a]]
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[[Category: Serine esterase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:05:38 2008''
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Current revision

PP2A-specific methylesterase apo form (PME)

PDB ID 3c5v

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