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3c8e

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{{Seed}}
 
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[[Image:3c8e.jpg|left|200px]]
 
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==Crystal Structure Analysis of yghU from E. Coli==
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The line below this paragraph, containing "STRUCTURE_3c8e", creates the "Structure Box" on the page.
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<StructureSection load='3c8e' size='340' side='right'caption='[[3c8e]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C8E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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{{STRUCTURE_3c8e| PDB=3c8e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8e OCA], [https://pdbe.org/3c8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c8e RCSB], [https://www.ebi.ac.uk/pdbsum/3c8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8e ProSAT]</span></td></tr>
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</table>
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===Crystal Structure Analysis of yghU from E. Coli===
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== Function ==
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[https://www.uniprot.org/uniprot/YGHU_ECOLI YGHU_ECOLI] Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert-butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3C8E is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8E OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/3c8e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c8e ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Armstrong, R N.]]
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[[Category: Large Structures]]
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[[Category: Harp, J.]]
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[[Category: Armstrong RN]]
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[[Category: Ladner, J E.]]
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[[Category: Harp J]]
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[[Category: Schaab, M R.]]
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[[Category: Ladner JE]]
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[[Category: Stourman, N V.]]
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[[Category: Schaab MR]]
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[[Category: E. coli]]
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[[Category: Stourman NV]]
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[[Category: Glutathione transferase homologue]]
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[[Category: Yghu]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:27:17 2009''
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Current revision

Crystal Structure Analysis of yghU from E. Coli

PDB ID 3c8e

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