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3cfp

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{{Seed}}
 
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[[Image:3cfp.jpg|left|200px]]
 
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==Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 1==
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The line below this paragraph, containing "STRUCTURE_3cfp", creates the "Structure Box" on the page.
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<StructureSection load='3cfp' size='340' side='right'caption='[[3cfp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cfp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_RB69 Escherichia phage RB69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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{{STRUCTURE_3cfp| PDB=3cfp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfp OCA], [https://pdbe.org/3cfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfp RCSB], [https://www.ebi.ac.uk/pdbsum/3cfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfp ConSurf].
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<div style="clear:both"></div>
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===Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 1===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3CFP is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_rb69 Enterobacteria phage rb69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFP OCA].
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[[Category: Escherichia phage RB69]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Klimenko D]]
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<ref group="xtra">PMID:9215631</ref><ref group="xtra">PMID:11389835</ref><references group="xtra"/>
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[[Category: Konigsberg WH]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Steitz TA]]
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[[Category: Enterobacteria phage rb69]]
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[[Category: Wang J]]
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[[Category: Klimenko, D.]]
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[[Category: Wang M]]
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[[Category: Konigsberg, W H.]]
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[[Category: Steitz, T A.]]
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[[Category: Wang, J.]]
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[[Category: Wang, M.]]
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[[Category: Catalytic complex]]
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[[Category: Dna polymerase]]
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[[Category: Dna replication]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Exonuclease]]
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[[Category: Fidelity]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Transferase]]
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[[Category: Transferase/dna complex]]
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[[Category: Two metal ion mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:23:28 2009''
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Current revision

Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 1

PDB ID 3cfp

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