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3chp

From Proteopedia

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[[Image:3chp.png|left|200px]]
 
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{{STRUCTURE_3chp| PDB=3chp | SCENE= }}
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==Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid==
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<StructureSection load='3chp' size='340' side='right'caption='[[3chp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3chp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CHP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18394906}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4BO:(3S)-3-AMINO-4-OXO-4-[(4-PHENYLMETHOXYPHENYL)AMINO]BUTANOIC+ACID'>4BO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3chp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3chp OCA], [https://pdbe.org/3chp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3chp RCSB], [https://www.ebi.ac.uk/pdbsum/3chp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3chp ProSAT]</span></td></tr>
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[[3chp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3chp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3chp ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Leukotriene A4 Hydrolase|Leukotriene A4 Hydrolase]]
*[[Leukotriene A4 Hydrolase|Leukotriene A4 Hydrolase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018394906</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Adler, M.]]
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[[Category: Large Structures]]
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[[Category: Thunnissen, M M.G M.]]
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[[Category: Adler M]]
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[[Category: Whitlow, M.]]
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[[Category: Thunnissen MMGM]]
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[[Category: Alpha-beta protein]]
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[[Category: Whitlow M]]
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[[Category: Epoxide hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor complex]]
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[[Category: Leukotriene biosynthesis]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Multifunctional enzyme]]
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Current revision

Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid

PDB ID 3chp

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