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3cjw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3cjw is ON HOLD Authors: Kruse, S.W., Reynolds, R., Vonrhein, C., Xu, H.E. Description: Crystal structure of the human COUP-TFII ligand binding dom...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human COUP-TFII ligand binding domain== | |
| - | + | <StructureSection load='3cjw' size='340' side='right'caption='[[3cjw]], [[Resolution|resolution]] 1.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3cjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjw OCA], [https://pdbe.org/3cjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cjw RCSB], [https://www.ebi.ac.uk/pdbsum/3cjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjw ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/COT2_HUMAN COT2_HUMAN] Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.<ref>PMID:1899293</ref> <ref>PMID:9343308</ref> <ref>PMID:18798693</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cjw_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cjw ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kruse SW]] | ||
| + | [[Category: Reynolds R]] | ||
| + | [[Category: Vonrhein C]] | ||
| + | [[Category: Xu HE]] | ||
Current revision
Crystal structure of the human COUP-TFII ligand binding domain
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