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3cjw

From Proteopedia

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{{Seed}}
 
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[[Image:3cjw.jpg|left|200px]]
 
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==Crystal structure of the human COUP-TFII ligand binding domain==
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The line below this paragraph, containing "STRUCTURE_3cjw", creates the "Structure Box" on the page.
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<StructureSection load='3cjw' size='340' side='right'caption='[[3cjw]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjw OCA], [https://pdbe.org/3cjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cjw RCSB], [https://www.ebi.ac.uk/pdbsum/3cjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjw ProSAT]</span></td></tr>
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{{STRUCTURE_3cjw| PDB=3cjw | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the human COUP-TFII ligand binding domain===
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[https://www.uniprot.org/uniprot/COT2_HUMAN COT2_HUMAN] Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.<ref>PMID:1899293</ref> <ref>PMID:9343308</ref> <ref>PMID:18798693</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18798693 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cjw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18798693}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cjw ConSurf].
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3CJW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJW OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor., Kruse SW, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, Vonrhein C, Xu Y, Wang L, Tsai SY, Tsai MJ, Xu HE, PLoS Biol. 2008 Sep 16;6(9):e227. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18798693 18798693]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kruse, S W.]]
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[[Category: Kruse SW]]
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[[Category: Reynolds, R.]]
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[[Category: Reynolds R]]
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[[Category: Vonrhein, C.]]
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[[Category: Vonrhein C]]
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[[Category: Xu, H E.]]
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[[Category: Xu HE]]
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[[Category: Coup-tfii]]
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[[Category: Dna-binding]]
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[[Category: Ligand binding domain]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Orphan receptor]]
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[[Category: Receptor]]
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[[Category: Three-layered helical sandwich]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:27:24 2008''
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Current revision

Crystal structure of the human COUP-TFII ligand binding domain

PDB ID 3cjw

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