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3ckw
From Proteopedia
(Difference between revisions)
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==Crystal structure of sterile 20-like kinase 3 (MST3, STK24)== | ==Crystal structure of sterile 20-like kinase 3 (MST3, STK24)== | ||
| - | <StructureSection load='3ckw' size='340' side='right'caption='[[3ckw]]' scene=''> | + | <StructureSection load='3ckw' size='340' side='right'caption='[[3ckw]], [[Resolution|resolution]] 1.96Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3ckw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckw OCA], [https://pdbe.org/3ckw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckw RCSB], [https://www.ebi.ac.uk/pdbsum/3ckw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckw ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3ckw TOPSAN]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckw OCA], [https://pdbe.org/3ckw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckw RCSB], [https://www.ebi.ac.uk/pdbsum/3ckw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckw ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3ckw TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Antonysamy SS]] | [[Category: Antonysamy SS]] | ||
Current revision
Crystal structure of sterile 20-like kinase 3 (MST3, STK24)
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Categories: Homo sapiens | Large Structures | Antonysamy SS | Buchanan S | Burley SK | Chau F | Feil I | Sauder JM | Wu L
