3cm9
From Proteopedia
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| - | {{STRUCTURE_3cm9| PDB=3cm9 | SCENE= }} | ||
| - | ===Solution Structure of Human SIgA2=== | ||
| - | {{ABSTRACT_PUBMED_19109255}} | ||
| - | == | + | ==Solution Structure of Human SIgA2== |
| - | [[3cm9]] is a 10 chain structure with sequence from [ | + | <StructureSection load='3cm9' size='340' side='right'caption='[[3cm9]]' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3cm9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CM9 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cm9 OCA], [https://pdbe.org/3cm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3cm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cm9 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/3cm9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cm9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Almogren A]] |
| - | [[Category: | + | [[Category: Bonner A]] |
| - | + | [[Category: Furtado PB]] | |
| - | [[Category: | + | [[Category: Kerr MA]] |
| - | [[Category: | + | [[Category: Perkins SJ]] |
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Current revision
Solution Structure of Human SIgA2
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