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3cr5

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{{Seed}}
 
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[[Image:3cr5.png|left|200px]]
 
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==X-ray structure of bovine Pnt-Zn(2+),Ca(2+)-S100B==
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The line below this paragraph, containing "STRUCTURE_3cr5", creates the "Structure Box" on the page.
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<StructureSection load='3cr5' size='340' side='right'caption='[[3cr5]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CR5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PNT:1,5-BIS(4-AMIDINOPHENOXY)PENTANE'>PNT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3cr5| PDB=3cr5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cr5 OCA], [https://pdbe.org/3cr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cr5 RCSB], [https://www.ebi.ac.uk/pdbsum/3cr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cr5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/3cr5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cr5 ConSurf].
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<div style="clear:both"></div>
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===X-ray structure of bovine Pnt-Zn(2+),Ca(2+)-S100B===
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18602402 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18602402}}
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==About this Structure==
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3CR5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CR5 OCA].
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==Reference==
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Divalent Metal Ion Complexes of S100B in the Absence and Presence of Pentamidine., Charpentier TH, Wilder PT, Liriano MA, Varney KM, Pozharski E, Mackerell AD Jr, Coop A, Toth EA, Weber DJ, J Mol Biol. 2008 Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18602402 18602402]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Charpentier TH]]
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[[Category: Acetylation]]
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[[Category: Alpha helical]]
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[[Category: Calcium]]
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[[Category: Cytoplasm]]
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[[Category: Ef hand]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 20:40:33 2009''
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Current revision

X-ray structure of bovine Pnt-Zn(2+),Ca(2+)-S100B

PDB ID 3cr5

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