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3crh

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{{Seed}}
 
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[[Image:3crh.jpg|left|200px]]
 
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<!--
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==Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala==
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The line below this paragraph, containing "STRUCTURE_3crh", creates the "Structure Box" on the page.
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<StructureSection load='3crh' size='340' side='right'caption='[[3crh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3crh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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-->
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3crh| PDB=3crh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3crh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3crh OCA], [https://pdbe.org/3crh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3crh RCSB], [https://www.ebi.ac.uk/pdbsum/3crh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3crh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/3crh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3crh ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala===
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==See Also==
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*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3CRH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRH OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blaber, M.]]
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[[Category: Large Structures]]
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[[Category: Honjo, E.]]
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[[Category: Blaber M]]
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[[Category: Kuroki, R.]]
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[[Category: Honjo E]]
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[[Category: Lee, J.]]
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[[Category: Kuroki R]]
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[[Category: Meher, A K.]]
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[[Category: Lee J]]
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[[Category: Somasundaram, T.]]
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[[Category: Meher AK]]
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[[Category: Acetylation]]
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[[Category: Somasundaram T]]
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[[Category: Angiogenesis]]
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[[Category: Crystal packing]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Growth factor]]
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[[Category: Heparin-binding]]
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[[Category: Hormone]]
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[[Category: Mitogen]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:22:36 2009''
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Current revision

Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala

PDB ID 3crh

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