3cs4

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{{Seed}}
 
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[[Image:3cs4.png|left|200px]]
 
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==Structure-based design of a superagonist ligand for the vitamin D nuclear receptor==
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The line below this paragraph, containing "STRUCTURE_3cs4", creates the "Structure Box" on the page.
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<StructureSection load='3cs4' size='340' side='right'caption='[[3cs4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cs4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CS4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COV:(1S,3R,5Z,7E,14BETA,17ALPHA)-17-[(2S,4S)-4-(2-HYDROXY-2-METHYLPROPYL)-2-METHYLTETRAHYDROFURAN-2-YL]-9,10-SECOANDROSTA-5,7,10-TRIENE-1,3-DIOL'>COV</scene></td></tr>
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{{STRUCTURE_3cs4| PDB=3cs4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cs4 OCA], [https://pdbe.org/3cs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cs4 RCSB], [https://www.ebi.ac.uk/pdbsum/3cs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cs4 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[https://omim.org/entry/277440 277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3cs4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cs4 ConSurf].
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<div style="clear:both"></div>
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===Structure-based design of a superagonist ligand for the vitamin D nuclear receptor===
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==See Also==
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*[[Sandbox vdr|Sandbox vdr]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_18420145}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 18420145 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_18420145}}
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==About this Structure==
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3CS4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CS4 OCA].
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==Reference==
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<ref group="xtra">PMID:18420145</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Antony, P.]]
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[[Category: Large Structures]]
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[[Category: Ciesielski, F.]]
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[[Category: Antony P]]
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[[Category: Hourai, S.]]
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[[Category: Ciesielski F]]
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[[Category: Magnier, B C.]]
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[[Category: Hourai S]]
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[[Category: Moras, D.]]
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[[Category: Magnier BC]]
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[[Category: Mourino, A.]]
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[[Category: Moras D]]
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[[Category: Reina-San-Martin, B.]]
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[[Category: Mourino A]]
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[[Category: Rochel, N.]]
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[[Category: Reina-San-Martin B]]
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[[Category: Rodriguez, L C.]]
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[[Category: Rochel N]]
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[[Category: Schoonjans, K.]]
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[[Category: Rodriguez LC]]
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[[Category: Disease mutation]]
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[[Category: Schoonjans K]]
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[[Category: Dna-binding]]
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[[Category: Gene regulation]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Superagonist]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Vdr]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:53:08 2009''
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Current revision

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

PDB ID 3cs4

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