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3cyi

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{{Seed}}
 
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[[Image:3cyi.png|left|200px]]
 
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<!--
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==Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+==
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The line below this paragraph, containing "STRUCTURE_3cyi", creates the "Structure Box" on the page.
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<StructureSection load='3cyi' size='340' side='right'caption='[[3cyi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CYI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3cyi| PDB=3cyi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyi OCA], [https://pdbe.org/3cyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cyi RCSB], [https://www.ebi.ac.uk/pdbsum/3cyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyi ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+===
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== Function ==
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[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18579529 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/3cyi_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18579529}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3CYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYI OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cyi ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Sulfiredoxin Proceeds Directly through a Sulfinic Phosphoryl Ester Intermediate., Jonsson TJ, Murray MS, Johnson LC, Lowther WT, J Biol Chem. 2008 Aug 29;283(35):23846-51. Epub 2008 Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18579529 18579529]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Sulfiredoxin]]
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[[Category: Johnson LC]]
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[[Category: Johnson, L C.]]
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[[Category: Jonsson TJ]]
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[[Category: Jonsson, T J]]
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[[Category: Lowther WT]]
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[[Category: Lowther, W T.]]
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[[Category: Murray MS]]
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[[Category: Murray, M S.]]
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[[Category: Antioxidant]]
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[[Category: Atp-binding]]
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[[Category: Cys sulfinic acid reduction]]
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[[Category: Cytoplasm]]
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[[Category: Magnesium]]
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[[Category: Nucleotide-binding]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 08:59:31 2008''
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Current revision

Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+

PDB ID 3cyi

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