3d0s

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[[Image:3d0s.png|left|200px]]
 
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{{STRUCTURE_3d0s| PDB=3d0s | SCENE= }}
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==cAMP receptor protein from m.tuberculosis, cAMP-free form==
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<StructureSection load='3d0s' size='340' side='right'caption='[[3d0s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3d0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D0S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d0s OCA], [https://pdbe.org/3d0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d0s RCSB], [https://www.ebi.ac.uk/pdbsum/3d0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d0s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRPL_MYCTU CRPL_MYCTU] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled.<ref>PMID:15882420</ref> <ref>PMID:20028978</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/3d0s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d0s ConSurf].
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<div style="clear:both"></div>
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===cAMP receptor protein from m.tuberculosis, cAMP-free form===
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==See Also==
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3d0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0S OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Gallagher, D T.]]
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[[Category: Gallagher DT]]
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[[Category: Reddy, P T.]]
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[[Category: Reddy PT]]
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[[Category: Robinson, H.]]
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[[Category: Robinson H]]
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[[Category: Allostery]]
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[[Category: Catabolite gene activator protein]]
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[[Category: Cyclic amp]]
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[[Category: Dimer]]
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[[Category: Dna binding]]
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[[Category: Dna-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

cAMP receptor protein from m.tuberculosis, cAMP-free form

PDB ID 3d0s

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