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3d4v

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{{Seed}}
 
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[[Image:3d4v.jpg|left|200px]]
 
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==Crystal Structure of an AlkA Host/Guest Complex N7MethylGuanine:Cytosine Base Pair==
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The line below this paragraph, containing "STRUCTURE_3d4v", creates the "Structure Box" on the page.
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<StructureSection load='3d4v' size='340' side='right'caption='[[3d4v]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d4v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D4V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMG:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-7-METHYL-6-OXO-6,9-DIHYDRO-1H-PURIN-7-IUM'>FMG</scene></td></tr>
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{{STRUCTURE_3d4v| PDB=3d4v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d4v OCA], [https://pdbe.org/3d4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d4v RCSB], [https://www.ebi.ac.uk/pdbsum/3d4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d4v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3MG2_ECOLI 3MG2_ECOLI] Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/3d4v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d4v ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of an AlkA Host/Guest Complex N7MethylGuanine:Cytosine Base Pair===
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3D4V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4V OCA].
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==Reference==
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Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine., Lee S, Bowman BR, Ueno Y, Wang S, Verdine GL, J Am Chem Soc. 2008 Sep 3;130(35):11570-1. Epub 2008 Aug 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18686953 18686953]
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[[Category: DNA-3-methyladenine glycosylase II]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bowman, B R.]]
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[[Category: Bowman BR]]
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[[Category: Lee, S.]]
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[[Category: Lee S]]
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[[Category: Verdine, G L.]]
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[[Category: Verdine GL]]
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[[Category: Wang, S.]]
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[[Category: Wang S]]
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[[Category: Alka]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna structure]]
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[[Category: Host/guest complex]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase/dna complex]]
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[[Category: N7methylguanine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 10:44:01 2008''
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Current revision

Crystal Structure of an AlkA Host/Guest Complex N7MethylGuanine:Cytosine Base Pair

PDB ID 3d4v

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