This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3e4z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:44, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3e4z.png|left|200px]]
 
-
<!--
+
==Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II==
-
The line below this paragraph, containing "STRUCTURE_3e4z", creates the "Structure Box" on the page.
+
<StructureSection load='3e4z' size='340' side='right'caption='[[3e4z]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3e4z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4Z FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_3e4z| PDB=3e4z | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4z OCA], [https://pdbe.org/3e4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4z RCSB], [https://www.ebi.ac.uk/pdbsum/3e4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4z ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/3e4z_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e4z ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II===
+
==See Also==
-
 
+
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
-
 
+
*[[Insulin-like growth factor|Insulin-like growth factor]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19896952}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19896952 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_19896952}}
+
-
 
+
-
==Disease==
+
-
Known disease associated with this structure: Intrauterine and postnatal growth retardation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147470 147470]]
+
-
 
+
-
==About this Structure==
+
-
3E4Z is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4Z OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19896952</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Insulysin]]
+
[[Category: Large Structures]]
-
[[Category: Guo, Q.]]
+
[[Category: Guo Q]]
-
[[Category: Manolopoulou, M.]]
+
[[Category: Manolopoulou M]]
-
[[Category: Tang, W J.]]
+
[[Category: Tang W-J]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Complex]]
+
-
[[Category: Degrading]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Growth factor]]
+
-
[[Category: Hydrolase/hormone complex]]
+
-
[[Category: Ide]]
+
-
[[Category: Igf-ii]]
+
-
[[Category: Mitogen]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Secreted]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 15:53:16 2010''
+

Current revision

Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II

PDB ID 3e4z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3e4z"
Personal tools