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3e4z

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{{STRUCTURE_3e4z| PDB=3e4z | SCENE= }}
 
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===Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II===
 
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{{ABSTRACT_PUBMED_19896952}}
 
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==Disease==
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==Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II==
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[[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:[http://omim.org/entry/180860 180860]]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.<ref>PMID:19066168</ref>
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<StructureSection load='3e4z' size='340' side='right'caption='[[3e4z]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3e4z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4Z FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.<ref>PMID:16912056</ref> Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.<ref>PMID:16912056</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4z OCA], [https://pdbe.org/3e4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4z RCSB], [https://www.ebi.ac.uk/pdbsum/3e4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4z ProSAT]</span></td></tr>
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[[3e4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4Z OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/3e4z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e4z ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]]
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*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
*[[Insulin-like growth factor|Insulin-like growth factor]]
*[[Insulin-like growth factor|Insulin-like growth factor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019896952</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Insulysin]]
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[[Category: Large Structures]]
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[[Category: Guo, Q.]]
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[[Category: Guo Q]]
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[[Category: Manolopoulou, M.]]
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[[Category: Manolopoulou M]]
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[[Category: Tang, W J.]]
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[[Category: Tang W-J]]
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[[Category: Complex]]
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[[Category: Degrading]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Hydrolase-hormone complex]]
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[[Category: Ide]]
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[[Category: Igf-ii]]
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[[Category: Mitogen]]
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[[Category: Secreted]]
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Current revision

Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II

PDB ID 3e4z

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