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3eay

From Proteopedia

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{{Seed}}
 
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[[Image:3eay.png|left|200px]]
 
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==Crystal structure of the human SENP7 catalytic domain==
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The line below this paragraph, containing "STRUCTURE_3eay", creates the "Structure Box" on the page.
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<StructureSection load='3eay' size='340' side='right'caption='[[3eay]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3eay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3eay| PDB=3eay | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eay OCA], [https://pdbe.org/3eay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eay RCSB], [https://www.ebi.ac.uk/pdbsum/3eay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eay ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SENP7_HUMAN SENP7_HUMAN] Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.<ref>PMID:18799455</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eay_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eay ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the human SENP7 catalytic domain===
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==See Also==
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*[[Sentrin-specific protease|Sentrin-specific protease]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18799455}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18799455 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18799455}}
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==About this Structure==
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3EAY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAY OCA].
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==Reference==
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Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7., Lima CD, Reverter D, J Biol Chem. 2008 Nov 14;283(46):32045-55. Epub 2008 Sep 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18799455 18799455]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lima, C D.]]
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[[Category: Large Structures]]
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[[Category: Reverter, D.]]
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[[Category: Lima CD]]
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[[Category: Alternative splicing]]
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[[Category: Reverter D]]
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[[Category: Crystal]]
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[[Category: Hydrolase]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Senp]]
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[[Category: Sentrin-specific protease]]
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[[Category: Sumo]]
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[[Category: Thiol protease]]
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[[Category: Ubiquitin]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Ulp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:53:14 2008''
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Current revision

Crystal structure of the human SENP7 catalytic domain

PDB ID 3eay

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