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3epo
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3epo is ON HOLD Authors: Li, S., Chatterjee, A., Zhang, Y., Grove, T.L., Lee, M., Krebs, C., Booker, S.J., Begley, T.P., Ealick, S.E. Description: ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P== | |
| - | + | <StructureSection load='3epo' size='340' side='right'caption='[[3epo]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3epo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MP5:(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL+DIHYDROGEN+PHOSPHATE'>MP5</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epo OCA], [https://pdbe.org/3epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epo RCSB], [https://www.ebi.ac.uk/pdbsum/3epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epo ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THIC_CAUVC THIC_CAUVC] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18953358</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epo_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epo ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caulobacter vibrioides]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Begley TP]] | ||
| + | [[Category: Booker SJ]] | ||
| + | [[Category: Chatterjee A]] | ||
| + | [[Category: Ealick SE]] | ||
| + | [[Category: Grove TL]] | ||
| + | [[Category: Krebs C]] | ||
| + | [[Category: Lee M]] | ||
| + | [[Category: Li S]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P
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Categories: Caulobacter vibrioides | Large Structures | Begley TP | Booker SJ | Chatterjee A | Ealick SE | Grove TL | Krebs C | Lee M | Li S | Zhang Y
