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3epp
From Proteopedia
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==Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin== | ==Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin== | ||
| - | <StructureSection load='3epp' size='340' side='right' caption='[[3epp]], [[Resolution|resolution]] 2.41Å' scene=''> | + | <StructureSection load='3epp' size='340' side='right'caption='[[3epp]], [[Resolution|resolution]] 2.41Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3epp]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3epp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epp OCA], [https://pdbe.org/3epp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epp RCSB], [https://www.ebi.ac.uk/pdbsum/3epp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epp ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epp_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epp_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epp ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Amaya | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Amaya MF]] |
| - | [[Category: Botchkarev | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Botchkarev A]] |
| - | [[Category: Edwards | + | [[Category: Bountra C]] |
| - | [[Category: Loppnau | + | [[Category: Edwards AM]] |
| - | [[Category: Min | + | [[Category: Loppnau P]] |
| - | [[Category: Plotnikov | + | [[Category: Min J]] |
| - | + | [[Category: Plotnikov AN]] | |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Wu | + | [[Category: Wu H]] |
| - | [[Category: Zeng | + | [[Category: Zeng H]] |
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Current revision
Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin
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Categories: Homo sapiens | Large Structures | Amaya MF | Arrowsmith CH | Botchkarev A | Bountra C | Edwards AM | Loppnau P | Min J | Plotnikov AN | Weigelt J | Wu H | Zeng H
