This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3epp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:48, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3epp.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin==
-
The line below this paragraph, containing "STRUCTURE_3epp", creates the "Structure Box" on the page.
+
<StructureSection load='3epp' size='340' side='right'caption='[[3epp]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3epp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPP FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr>
-
{{STRUCTURE_3epp| PDB=3epp | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epp OCA], [https://pdbe.org/3epp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epp RCSB], [https://www.ebi.ac.uk/pdbsum/3epp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epp ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
3EPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPP OCA].
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epp ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Amaya, M F.]]
+
[[Category: Amaya MF]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Botchkarev, A.]]
+
[[Category: Botchkarev A]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards AM]]
-
[[Category: Loppnau, P.]]
+
[[Category: Loppnau P]]
-
[[Category: Min, J.]]
+
[[Category: Min J]]
-
[[Category: Plotnikov, A N.]]
+
[[Category: Plotnikov AN]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Wu H]]
-
[[Category: Wu, H.]]
+
[[Category: Zeng H]]
-
[[Category: Zeng, H.]]
+
-
[[Category: Alternative splicing]]
+
-
[[Category: Mrna cap guanine-n7 methyltransferase]]
+
-
[[Category: Mrna capping]]
+
-
[[Category: Mrna processing]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Rna-binding]]
+
-
[[Category: Rnmt]]
+
-
[[Category: S-adenosyl-l-methionine]]
+
-
[[Category: Sgc]]
+
-
[[Category: Sinefungin]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 22 10:59:44 2008''
+

Current revision

Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin

PDB ID 3epp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3epp"
Personal tools