3g1m

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{{STRUCTURE_3g1m| PDB=3g1m | SCENE= }}
 
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===EthR from Mycobacterium tuberculosis in complex with compound BDM31381===
 
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{{ABSTRACT_PUBMED_19412174}}
 
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==Function==
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==EthR from Mycobacterium tuberculosis in complex with compound BDM31381==
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[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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<StructureSection load='3g1m' size='340' side='right'caption='[[3g1m]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G1M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RF3:1-(THIOPHEN-2-YLACETYL)-4-(3-THIOPHEN-2-YL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE'>RF3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g1m OCA], [https://pdbe.org/3g1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g1m RCSB], [https://www.ebi.ac.uk/pdbsum/3g1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g1m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g1/3g1m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g1m ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3g1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G1M OCA].
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019412174</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Aumercier, M.]]
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</StructureSection>
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[[Category: Baulard, A R.]]
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[[Category: Large Structures]]
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[[Category: Bifani, P.]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Carette, X.]]
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[[Category: Aumercier M]]
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[[Category: Delcroix, G.]]
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[[Category: Baulard AR]]
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[[Category: Deprez, B.]]
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[[Category: Bifani P]]
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[[Category: Deprez-Poulain, R.]]
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[[Category: Carette X]]
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[[Category: Desroses, M.]]
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[[Category: Delcroix G]]
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[[Category: Dirie, B.]]
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[[Category: Deprez B]]
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[[Category: Frenois, F.]]
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[[Category: Deprez-Poulain R]]
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[[Category: Leroux, F.]]
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[[Category: Desroses M]]
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[[Category: Locht, C.]]
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[[Category: Dirie B]]
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[[Category: Mathys, V.]]
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[[Category: Frenois F]]
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[[Category: Singhal, A.]]
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[[Category: Leroux F]]
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[[Category: Villeret, V.]]
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[[Category: Locht C]]
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[[Category: Willand, N.]]
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[[Category: Mathys V]]
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[[Category: Willery, E.]]
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[[Category: Singhal A]]
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[[Category: Dna-binding]]
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[[Category: Villeret V]]
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[[Category: Tetr family]]
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[[Category: Willand N]]
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[[Category: Transcription]]
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[[Category: Willery E]]
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[[Category: Transcription regulation]]
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Current revision

EthR from Mycobacterium tuberculosis in complex with compound BDM31381

PDB ID 3g1m

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