3g8q

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==A cytidine deaminase edits C-to-U in transfer RNAs in archaea==
==A cytidine deaminase edits C-to-U in transfer RNAs in archaea==
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<StructureSection load='3g8q' size='340' side='right' caption='[[3g8q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3g8q' size='340' side='right'caption='[[3g8q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3g8q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanopyrus_kandleri Methanopyrus kandleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3g8q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri Methanopyrus kandleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MK0935 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2320 Methanopyrus kandleri])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8q RCSB], [http://www.ebi.ac.uk/pdbsum/3g8q PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8q OCA], [https://pdbe.org/3g8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8q RCSB], [https://www.ebi.ac.uk/pdbsum/3g8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8q ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/CDAT8_METKA CDAT8_METKA] Catalyzes the deamimation of cytosine to uracil at position 8 of tRNA in 30 different tRNAs. This editing guarantees the proper folding and functionality of the tRNAs.<ref>PMID:19407206</ref>
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All canonical transfer RNAs (tRNAs) have a uridine at position 8, involved in maintaining tRNA tertiary structure. However, the hyperthermophilic archaeon Methanopyrus kandleri harbors 30 (out of 34) tRNA genes with cytidine at position 8. Here, we demonstrate C-to-U editing at this location in the tRNA's tertiary core, and present the crystal structure of a tRNA-specific cytidine deaminase, CDAT8, which has the cytidine deaminase domain linked to a tRNA-binding THUMP domain. CDAT8 is specific for C deamination at position 8, requires only the acceptor stem hairpin for activity, and belongs to a unique family within the "cytidine deaminase-like" superfamily. The presence of this C-to-U editing enzyme guarantees the proper folding and functionality of all M. kandleri tRNAs.
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A cytidine deaminase edits C to U in transfer RNAs in Archaea.,Randau L, Stanley BJ, Kohlway A, Mechta S, Xiong Y, Soll D Science. 2009 May 1;324(5927):657-9. PMID:19407206<ref>PMID:19407206</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanopyrus kandleri]]
[[Category: Methanopyrus kandleri]]
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[[Category: Stanley, B J]]
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[[Category: Stanley BJ]]
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[[Category: Xiong, Y]]
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[[Category: Xiong Y]]
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[[Category: Cytidine deaminase]]
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[[Category: Ferredoxin-like domain]]
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[[Category: Rna binding protein]]
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[[Category: Thump]]
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Current revision

A cytidine deaminase edits C-to-U in transfer RNAs in archaea

PDB ID 3g8q

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