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3gd8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3gd8 is ON HOLD Authors: Ho, J.D., Yeh, R., Sandstrom, A., Chorny, I., Harries, W.E.C., Robbins, R.A., Miercke, L.J.W., Stroud, R.M., Center for Str...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance== | |
| + | <StructureSection load='3gd8' size='340' side='right'caption='[[3gd8]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3gd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GD8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gd8 OCA], [https://pdbe.org/3gd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3gd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gd8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AQP4_HUMAN AQP4_HUMAN] Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/3gd8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gd8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Aquaporin 3D structures|Aquaporin 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chorny I]] | ||
| + | [[Category: Harries WEC]] | ||
| + | [[Category: Ho JD]] | ||
| + | [[Category: Miercke LJW]] | ||
| + | [[Category: Robbins RA]] | ||
| + | [[Category: Sandstrom A]] | ||
| + | [[Category: Stroud RM]] | ||
| + | [[Category: Yeh R]] | ||
Current revision
Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance
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Categories: Homo sapiens | Large Structures | Chorny I | Harries WEC | Ho JD | Miercke LJW | Robbins RA | Sandstrom A | Stroud RM | Yeh R
