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3h0q

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[[Image:3h0q.png|left|200px]]
 
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{{STRUCTURE_3h0q| PDB=3h0q | SCENE= }}
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==Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3==
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<StructureSection load='3h0q' size='340' side='right'caption='[[3h0q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3h0q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H0Q FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20219367}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B37:4-({4-[(2-METHYLQUINOLIN-6-YL)METHYL]PIPERIDIN-1-YL}CARBONYL)-2-PHENYLQUINOLINE'>B37</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0q OCA], [https://pdbe.org/3h0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h0q RCSB], [https://www.ebi.ac.uk/pdbsum/3h0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0q ProSAT]</span></td></tr>
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[[3h0q]] is a 3 chain structure of [[Acetyl-CoA carboxylase]] and [[Biotin carboxylase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0Q OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/3h0q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h0q ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
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*[[Biotin carboxylase|Biotin carboxylase]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:020219367</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Acetyl-coa carboxylase]]
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[[Category: Carboxyltransferase]]
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[[Category: Inhibitor]]
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[[Category: Ligase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3

PDB ID 3h0q

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