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3ha4

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==Crystal structure of the type one membrane protein MIX1 from Leishmania==
==Crystal structure of the type one membrane protein MIX1 from Leishmania==
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<StructureSection load='3ha4' size='340' side='right' caption='[[3ha4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3ha4' size='340' side='right'caption='[[3ha4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ha4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HA4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ha4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HA4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LmjF08.1200 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ha4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ha4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ha4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ha4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ha4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ha4 OCA], [https://pdbe.org/3ha4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ha4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ha4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ha4 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4QI49_LEIMA Q4QI49_LEIMA]
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Infection by Leishmania and Trypanosoma causes severe disease and can be fatal. The reduced effectiveness of current treatments is largely due to drug resistance, hence the urgent need to develop new drugs, preferably against novel targets. We have recently identified a mitochondrial membrane-anchored protein, designated MIX, which occurs exclusively in these parasites and is essential for virulence. We have determined the crystal structure of Leishmania major MIX to a resolution of 2.4 A. MIX forms an all alpha-helical fold comprising seven alpha-helices that fold into a single domain. The distribution of helices is similar to a number of scaffold proteins, namely HEAT repeats, 14-3-3, and tetratricopeptide repeat proteins, suggesting that MIX mediates protein-protein interactions. Accordingly, using copurification and mass spectroscopy we were able to identify several proteins that may interact with MIX in vivo. Being parasite specific, MIX is a promising new drug target and, thus, the structure and potential interacting partners provide a basis for structure-guided drug discovery.
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Crystal structure of the Leishmania major MIX protein: A scaffold protein that mediates protein-protein interactions.,Gorman MA, Uboldi AD, Walsh PJ, Tan KS, Hansen G, Huyton T, Ji H, Curtis J, Kedzierski L, Papenfuss AT, Dogovski C, Perugini MA, Simpson RJ, Handman E, Parker MW Protein Sci. 2011 Jun;20(6):1060-8. doi: 10.1002/pro.631. Epub 2011 Apr, 27. PMID:21465610<ref>PMID:21465610</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: Gorman, M A]]
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[[Category: Gorman MA]]
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[[Category: Parker, M W]]
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[[Category: Parker MW]]
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[[Category: Walsh, P J]]
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[[Category: Walsh PJ]]
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[[Category: Helix-turn-helix]]
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[[Category: Tpr-like]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of the type one membrane protein MIX1 from Leishmania

PDB ID 3ha4

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