This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3hhn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3hhn" [edit=sysop:move=sysop])
Current revision (09:59, 21 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3hhn.png|left|200px]]
 
-
{{STRUCTURE_3hhn| PDB=3hhn | SCENE= }}
+
==Crystal structure of class I ligase ribozyme self-ligation product, in complex with U1A RBD==
-
 
+
<StructureSection load='3hhn' size='340' side='right'caption='[[3hhn]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
-
===Crystal structure of class I ligase ribozyme self-ligation product, in complex with U1A RBD===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3hhn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHN FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_19965478}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.987&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhn OCA], [https://pdbe.org/3hhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhn RCSB], [https://www.ebi.ac.uk/pdbsum/3hhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhn ProSAT]</span></td></tr>
-
[[3hhn]] is a 4 chain structure of [[Nucleoprotein]] and [[Ribozyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHN OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hhn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hhn ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Nucleoprotein|Nucleoprotein]]
+
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-
*[[Ribozyme|Ribozyme]]
+
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:019965478</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bagby, S C.]]
+
[[Category: Large Structures]]
-
[[Category: Bartel, D P.]]
+
[[Category: Bagby SC]]
-
[[Category: Grant, R A.]]
+
[[Category: Bartel DP]]
-
[[Category: Shechner, D M.]]
+
[[Category: Grant RA]]
-
[[Category: Catalytic rna]]
+
[[Category: Shechner DM]]
-
[[Category: Ligase ribozyme]]
+
-
[[Category: Ligase-rna complex]]
+
-
[[Category: Protein-rna complex]]
+
-
[[Category: Ribonucleoprotein]]
+
-
[[Category: Ribozyme]]
+
-
[[Category: Rna-binding]]
+

Current revision

Crystal structure of class I ligase ribozyme self-ligation product, in complex with U1A RBD

PDB ID 3hhn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3hhn"
Personal tools