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3ia3

From Proteopedia

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Current revision (10:04, 21 February 2024) (edit) (undo)
 
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[[Image:3ia3.png|left|200px]]
 
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==A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin==
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The line below this paragraph, containing "STRUCTURE_3ia3", creates the "Structure Box" on the page.
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<StructureSection load='3ia3' size='340' side='right'caption='[[3ia3]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ia3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_3ia3| PDB=3ia3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia3 OCA], [https://pdbe.org/3ia3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia3 ProSAT]</span></td></tr>
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</table>
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===A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin===
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== Function ==
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[https://www.uniprot.org/uniprot/AHSP_HUMAN AHSP_HUMAN] Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<ref>PMID:12066189</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19706593}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19706593 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ia3_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19706593}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3ia3]] is a 4 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA3 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ia3 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hemoglobin]]
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019706593</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Feng, L.]]
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[[Category: Large Structures]]
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[[Category: Jeffrey, P D.]]
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[[Category: Feng L]]
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[[Category: Shi, Y.]]
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[[Category: Jeffrey PD]]
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[[Category: Acetylation]]
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[[Category: Shi Y]]
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[[Category: Ahsp]]
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[[Category: Chaperone]]
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[[Category: Cis-proline]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Glycation]]
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[[Category: Glycoprotein]]
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[[Category: Heme]]
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[[Category: Hemoglobin]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Oxygen transport]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Stabilization]]
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[[Category: Transport]]
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Current revision

A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin

PDB ID 3ia3

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