This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ia5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:04, 21 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ia5.png|left|200px]]
 
-
{{STRUCTURE_3ia5| PDB=3ia5 | SCENE= }}
+
==Moritella profunda dihydrofolate reductase (DHFR)==
-
 
+
<StructureSection load='3ia5' size='340' side='right'caption='[[3ia5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
===Moritella profunda dihydrofolate reductase (DHFR)===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA5 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_19681091}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia5 OCA], [https://pdbe.org/3ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia5 ProSAT]</span></td></tr>
-
[[3ia5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA5 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ia5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ia5 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:019681091</ref><references group="xtra"/>
+
[[Category: Large Structures]]
-
[[Category: Dihydrofolate reductase]]
+
[[Category: Moritella profunda]]
[[Category: Moritella profunda]]
-
[[Category: Allemann, R K.]]
+
[[Category: Allemann RK]]
-
[[Category: Evans, R M.]]
+
[[Category: Evans RM]]
-
[[Category: Hay, S.]]
+
[[Category: Hay S]]
-
[[Category: Levy, C.]]
+
[[Category: Levy C]]
-
[[Category: Leys, D.]]
+
[[Category: Leys D]]
-
[[Category: Loveridge, E J.]]
+
[[Category: Loveridge EJ]]
-
[[Category: Scrutton, N S.]]
+
[[Category: Scrutton NS]]
-
[[Category: Wang, X.]]
+
[[Category: Wang X]]
-
[[Category: Dhfr dihydrofolate reductase]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Moritella profunda dihydrofolate reductase (DHFR)

PDB ID 3ia5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ia5"
Personal tools