This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3iho

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:05, 21 February 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==The C-terminal glycosylase domain of human MBD4==
==The C-terminal glycosylase domain of human MBD4==
-
<StructureSection load='3iho' size='340' side='right' caption='[[3iho]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='3iho' size='340' side='right'caption='[[3iho]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3iho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IHO FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3iho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHO FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MBD4, MED1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iho OCA], [http://pdbe.org/3iho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iho RCSB], [http://www.ebi.ac.uk/pdbsum/3iho PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iho OCA], [https://pdbe.org/3iho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iho RCSB], [https://www.ebi.ac.uk/pdbsum/3iho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iho ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>
+
[https://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3iho_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3iho_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 20: Line 21:
==See Also==
==See Also==
-
*[[Methyl CpG binding protein|Methyl CpG binding protein]]
+
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Amaya, M F]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Amaya MF]]
-
[[Category: Bian, C B]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A]]
+
[[Category: Bian CB]]
-
[[Category: Bountra, C]]
+
[[Category: Bochkarev A]]
-
[[Category: Edwards, A M]]
+
[[Category: Bountra C]]
-
[[Category: Min, J]]
+
[[Category: Edwards AM]]
-
[[Category: Structural genomic]]
+
[[Category: Min J]]
-
[[Category: Weigelt, J]]
+
[[Category: Weigelt J]]
-
[[Category: Xu, C]]
+
[[Category: Xu C]]
-
[[Category: Dna damage]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Mbd4]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Sgc]]
+

Current revision

The C-terminal glycosylase domain of human MBD4

PDB ID 3iho

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3iho"
Personal tools