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3ipq

From Proteopedia

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{{Seed}}
 
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[[Image:3ipq.jpg|left|200px]]
 
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==X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha==
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The line below this paragraph, containing "STRUCTURE_3ipq", creates the "Structure Box" on the page.
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<StructureSection load='3ipq' size='340' side='right'caption='[[3ipq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ipq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=965:[3-(3-{[2-CHLORO-3-(TRIFLUOROMETHYL)BENZYL](2,2-DIPHENYLETHYL)AMINO}PROPOXY)PHENYL]ACETIC+ACID'>965</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ipq| PDB=3ipq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipq OCA], [https://pdbe.org/3ipq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipq RCSB], [https://www.ebi.ac.uk/pdbsum/3ipq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H3_HUMAN NR1H3_HUMAN] Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ipq ConSurf].
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<div style="clear:both"></div>
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===X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha===
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==See Also==
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*[[Liver X receptor|Liver X receptor]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3IPQ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPQ OCA].
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bennet, D J.]]
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[[Category: Large Structures]]
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[[Category: Cooke, A J.]]
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[[Category: Bennet DJ]]
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[[Category: Fradera, X.]]
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[[Category: Cooke AJ]]
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[[Category: Haunso, A.]]
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[[Category: Fradera X]]
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[[Category: Hosfield, D.]]
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[[Category: Haunso A]]
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[[Category: King, A.]]
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[[Category: Hosfield D]]
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[[Category: McGuire, R.]]
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[[Category: King A]]
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[[Category: Nimz, O.]]
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[[Category: McGuire R]]
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[[Category: Skene, R.]]
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[[Category: Nimz O]]
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[[Category: Uitdehaag, J C.M.]]
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[[Category: Skene R]]
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[[Category: Vu, D.]]
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[[Category: Uitdehaag JCM]]
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[[Category: Wijnands, R.]]
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[[Category: Vu D]]
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[[Category: Activator]]
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[[Category: Wijnands R]]
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[[Category: Acyltransferase]]
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[[Category: Alternative splicing]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Dna-binding]]
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[[Category: Isopeptide bond]]
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[[Category: Lxr homodimer]]
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[[Category: Lxr signaling]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Proto-oncogene]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:37:59 2010''
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Current revision

X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha

PDB ID 3ipq

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