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3iu2
From Proteopedia
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==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096== | ==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096== | ||
| - | <StructureSection load='3iu2' size='340' side='right' caption='[[3iu2]], [[Resolution|resolution]] 1.73Å' scene=''> | + | <StructureSection load='3iu2' size='340' side='right'caption='[[3iu2]], [[Resolution|resolution]] 1.73Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3iu2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3iu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=096:(2R)-2-{4-HYDROXY-5-METHOXY-2-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]PHENYL}-3-PYRIDIN-3-YL-1,3-THIAZOLIDIN-4-ONE'>096</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=096:(2R)-2-{4-HYDROXY-5-METHOXY-2-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]PHENYL}-3-PYRIDIN-3-YL-1,3-THIAZOLIDIN-4-ONE'>096</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu2 OCA], [https://pdbe.org/3iu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu2 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu2 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Brand | + | [[Category: Brand SY]] |
| - | [[Category: Cossar | + | [[Category: Cossar D]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Ferguson | + | [[Category: Ferguson MAJ]] |
| - | [[Category: Frearson | + | [[Category: Frearson JA]] |
| - | [[Category: Hui | + | [[Category: Hui R]] |
| - | [[Category: Hutchinson | + | [[Category: Hutchinson A]] |
| - | [[Category: Kania | + | [[Category: Kania A]] |
| - | [[Category: Kozieradzki | + | [[Category: Kozieradzki I]] |
| - | [[Category: Lin | + | [[Category: Lin Y-H]] |
| - | [[Category: Qiu | + | [[Category: Qiu W]] |
| - | [[Category: Ravichandran | + | [[Category: Ravichandran M]] |
| - | [[Category: Robinson | + | [[Category: Robinson DA]] |
| - | + | [[Category: Schapira M]] | |
| - | [[Category: Schapira | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Wernimont A]] |
| - | [[Category: Wernimont | + | [[Category: Wyatt PG]] |
| - | [[Category: Wyatt | + | |
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Current revision
Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Bountra C | Brand SY | Cossar D | Edwards AM | Ferguson MAJ | Frearson JA | Hui R | Hutchinson A | Kania A | Kozieradzki I | Lin Y-H | Qiu W | Ravichandran M | Robinson DA | Schapira M | Weigelt J | Wernimont A | Wyatt PG
