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3ivq

From Proteopedia

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{{Seed}}
 
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[[Image:3ivq.jpg|left|200px]]
 
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==Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2==
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The line below this paragraph, containing "STRUCTURE_3ivq", creates the "Structure Box" on the page.
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<StructureSection load='3ivq' size='340' side='right'caption='[[3ivq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ivq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IVQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ivq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivq OCA], [https://pdbe.org/3ivq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ivq RCSB], [https://www.ebi.ac.uk/pdbsum/3ivq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivq ProSAT]</span></td></tr>
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{{STRUCTURE_3ivq| PDB=3ivq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3ivq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ivq ConSurf].
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<div style="clear:both"></div>
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===Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2===
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==See Also==
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*[[Speckle-type POZ protein 3D structures|Speckle-type POZ protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19818708}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19818708 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19818708}}
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==About this Structure==
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3IVQ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVQ OCA].
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==Reference==
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<ref group="xtra">PMID:19818708</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Calabrese, M F.]]
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[[Category: Large Structures]]
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[[Category: Miller, D J.]]
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[[Category: Calabrese MF]]
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[[Category: Schulman, B A.]]
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[[Category: Miller DJ]]
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[[Category: Seyedin, S.]]
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[[Category: Schulman BA]]
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[[Category: Ligase]]
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[[Category: Seyedin S]]
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[[Category: Nucleus]]
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[[Category: Protein binding]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:22:24 2009''
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Current revision

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2

PDB ID 3ivq

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