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3iwe

From Proteopedia

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{{Seed}}
 
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[[Image:3iwe.jpg|left|200px]]
 
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<!--
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==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646==
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The line below this paragraph, containing "STRUCTURE_3iwe", creates the "Structure Box" on the page.
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<StructureSection load='3iwe' size='340' side='right'caption='[[3iwe]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=646:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>646</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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{{STRUCTURE_3iwe| PDB=3iwe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwe OCA], [https://pdbe.org/3iwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwe RCSB], [https://www.ebi.ac.uk/pdbsum/3iwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwe ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646===
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== Function ==
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[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3IWE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWE OCA].
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Check<jmol>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwe ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Brand, S Y.]]
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[[Category: Bountra C]]
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[[Category: Cossar, D.]]
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[[Category: Brand SY]]
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[[Category: Edwards, A M.]]
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[[Category: Cossar D]]
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[[Category: Ferguson, M A.J.]]
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[[Category: Edwards AM]]
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[[Category: Frearson, J A.]]
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[[Category: Ferguson MAJ]]
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[[Category: Hui, R.]]
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[[Category: Frearson JA]]
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[[Category: Hutchinson, A.]]
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[[Category: Hui R]]
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[[Category: Kania, A.]]
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[[Category: Hutchinson A]]
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[[Category: Kozieradzki, I.]]
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[[Category: Kania A]]
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[[Category: Lin, Y H.]]
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[[Category: Kozieradzki I]]
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[[Category: Qiu, W.]]
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[[Category: Lin Y-H]]
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[[Category: Ravichandran, M.]]
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[[Category: Qiu W]]
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[[Category: Robinson, D A.]]
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[[Category: Ravichandran M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Robinson DA]]
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[[Category: Schapira, M.]]
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[[Category: Schapira M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wernimont, A.]]
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[[Category: Wernimont A]]
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[[Category: Wyatt, P G.]]
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[[Category: Wyatt PG]]
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[[Category: Acyltransferase]]
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[[Category: Alternative splicing]]
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[[Category: Cytoplasm]]
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[[Category: N-myristoyltransferase]]
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[[Category: Nmt]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 09:15:14 2009''
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Current revision

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646

PDB ID 3iwe

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