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3j08

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<SX load='3j08' size='340' side='right' viewer='molstar' caption='[[3j08]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
<SX load='3j08' size='340' side='right' viewer='molstar' caption='[[3j08]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j08]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J08 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j08]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J08 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">copA, pacS, AF_0473 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j08 OCA], [https://pdbe.org/3j08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j08 RCSB], [https://www.ebi.ac.uk/pdbsum/3j08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j08 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j08 OCA], [https://pdbe.org/3j08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j08 RCSB], [https://www.ebi.ac.uk/pdbsum/3j08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j08 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/COPA_ARCFU COPA_ARCFU]] Probably involved in copper and silver export.<ref>PMID:11756450</ref>
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[https://www.uniprot.org/uniprot/COPA_ARCFU COPA_ARCFU] Probably involved in copper and silver export.<ref>PMID:11756450</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CopA uses ATP to pump Cu(+) across cell membranes. X-ray crystallography has defined atomic structures of several related P-type ATPases. We have determined a structure of CopA at 10 A resolution by cryo-electron microscopy of a new crystal form and used computational molecular docking to study the interactions between the N-terminal metal-binding domain (NMBD) and other elements of the molecule. We found that the shorter-chain lipids used to produce these crystals are associated with movements of the cytoplasmic domains, with a novel dimer interface and with disordering of the NMBD, thus offering evidence for the transience of its interaction with the other cytoplasmic domains. Docking identified a binding site that matched the location of the NMBD in our previous structure by cryo-electron microscopy, allowing a more detailed view of its binding configuration and further support for its role in autoinhibition.
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The Architecture of CopA from Archeaoglobus fulgidus Studied by Cryo-Electron Microscopy and Computational Docking.,Allen GS, Wu CC, Cardozo T, Stokes DL Structure. 2011 Aug 3. PMID:21820315<ref>PMID:21820315</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3j08" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Arcfl]]
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[[Category: Archaeoglobus fulgidus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allen, G S]]
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[[Category: Allen GS]]
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[[Category: Cardozo, T]]
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[[Category: Cardozo T]]
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[[Category: Stokes, D L]]
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[[Category: Stokes DL]]
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[[Category: Wu, C]]
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[[Category: Wu C]]
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[[Category: Adenosine triphosphatase]]
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[[Category: Archaeal protein]]
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[[Category: Cation transport protein]]
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[[Category: Copa]]
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[[Category: Copper transporter]]
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[[Category: Cryoelectron microscopy]]
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[[Category: Hydrolase]]
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[[Category: Metal transport]]
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[[Category: P-type atpase]]
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Current revision

High resolution helical reconstruction of the bacterial p-type ATPase copper transporter CopA

3j08, resolution 10.00Å

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OCA

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