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3j45

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'''Unreleased structure'''
 
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The entry 3j45 is ON HOLD until Paper Publication
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==Structure of a non-translocating SecY protein channel with the 70S ribosome==
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<SX load='3j45' size='340' side='right' viewer='molstar' caption='[[3j45]], [[Resolution|resolution]] 9.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j45]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J45 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j45 OCA], [https://pdbe.org/3j45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j45 RCSB], [https://www.ebi.ac.uk/pdbsum/3j45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j45 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECY_ECOLI SECY_ECOLI] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY.[HAMAP-Rule:MF_01465]
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Authors: Menetret, J.F., Park, E., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A., Akey, C.W.
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==See Also==
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*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
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Description: Structure of a non-translocating SecY protein channel with the 70S ribosome
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L24|Ribosomal protein L24]]
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*[[Ribosomal protein L29|Ribosomal protein L29]]
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__TOC__
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</SX>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Akey CW]]
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[[Category: Gumbart JC]]
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[[Category: Li W]]
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[[Category: Ludtke SJ]]
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[[Category: Menetret JF]]
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[[Category: Park E]]
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[[Category: Rapoport TA]]
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[[Category: Whynot A]]

Current revision

Structure of a non-translocating SecY protein channel with the 70S ribosome

3j45, resolution 9.50Å

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